In this Perspective, the authors summarize the current knowledge on the post-COVID-19 condition, focusing on the neurological manifestations, and discuss the applicability of existing animal models to recapitulate human condition.

Poor replicability in animal research can be a result of low external validity driven by rigorous standardization of study populations. This study investigates how heterogenization of study populations by using mice from different breeding sites might affect the replicability of animal studies conducted in a single facility. The findings suggest that heterogenization by breeding site has limited capacity to improve replicability in animal research.

The 3R principles provide an ethical framework for animal research throughout the world. However, despite the increasing awareness of these principles, there is still a lot of room for improving their implementation, especially when it comes to reduction. By combining Bayesian statistics with a shift in experimental design, here we present an entirely new idea to reduce animal numbers within experiments.

This article describes a computational model to forecast population dynamics in a laboratory colony of common marmosets. The model can be used to predict future animal stock levels and support colony management.

The study shows that, compared with lean animals, obesity significantly impacts echocardiographic findings, infarct size, circulating biomarkers, mitochondrial respiratory capacity and mortality in a minipig model of myocardial infarction.

The authors used an implantable electrophysiological device to assess the effects of two commonly used anesthetics (isoflurane and pentobarbital) on supraventricular electrophysiology and arrhythmic substrate in male and female rats.

The authors compare muscle function, histology and molecular markers, and biochemical plasma profiles in male and female HSA^LR mice to identify potential sex differences in this mouse model of myotonic dystrophy type I.

Wound healing assays are commonly used to study tissue repair in mice. The authors show that wound localization and housing conditions are critical factors that can affect the reliability and reproducibility of the results of this assay.

This study explores the use of electrical stunning as a viable alternative to anesthetic overdose and rapid cooling for euthanizing zebrafish larvae, potentially improving the welfare of over 5 million zebrafish in biomedical research.